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Report that Sunscreens Accelerate Cancer Jumps to Conclusions, Says FDA, Experts

by Grace Gold (Subscribe to Grace Gold's posts)
Posted May 26th 2010 at 12:15PM  
4 Comments
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Vitamin A in Sunscreen: Cancer-causing or overhyped? Photo: Getty Images

The sunscreen you apply to protect yourself and loved ones from skin cancer may actually speed up the growth of cancer cells, according to a new report that's making its way around the Internet.

But that statement assumes a leap that isn't entirely based on evidence, StyleList has found out.

The findings -- which were analyzed and broadcast by the Environmental Working Group -- looks at data from a 2009 FDA study of retinyl palmitate, a form of vitamin A that is often used in anti-aging cream formulations for its believed benefits as an antioxidant.

In the one-year study, cancerous cells developed 21 percent faster in lab mice who received an application of cream containing vitamin A than a control group who were treated with a vitamin-free version. Both lab groups were exposed to the equivalent of nine minutes of direct noontime Florida Sun every day for a year.

The EWG contends that the results point to vitamin A as a photocarcinogenic, meaning that the vitamin causes cancerous tumors when exposed to sunlight. "The evidence is troubling because the sunscreen industry adds vitamin A to 41 percent of all sunscreens," states the EWG in the report.

But an FDA spokesperson told StyleList that there is a vital detail that those jumping to conclusions are overlooking in the study; the fact that it tested plain vitamin A cream, not sunscreen containing vitamin A, on the mice.

"The FDA wanted more information about retinyl palmitate because it is exposed to sun when used on the skin. This study did not include a treatment of retinyl palmitate together with a sunscreen. It will be peer reviewed at the next Technical Report Review Subcommittee (TRRS) meeting to be held in January 2011. This review schedule is the standard procedure...it is premature to draw conclusions from the study at this time," the FDA told StyleList.

New York dermatologist Dr. Joshua Zeichner agrees that the absence of sunscreen in the study is a significant missing element. We've know for years that vitamin A and sun don't mix, as evidenced by FDA-imposed warnings on skincare drugs containing the substance -- such as Accutane or RetinA -- which warn users to avoid sun while undergoing treatment.

"Vitamin A derivatives are known to make people more sensitive to the sun because of thinning of the outer skin layer. It does not appear that the animals were given sunscreens. If the animals developed thinned skin, they would theoretically be more susceptible to ultraviolet light damage. This potentially could explain the higher risk of developing skin cancer," says Zeichner.

There is also the point that activity seen in animals does not necessarily mimic what would occur in humans.

"The concern comes from one study conducted on animals and not humans. Sometimes these animal studies are extrapolated to humans, when in reality it might have no relevance. We can not eliminate many years of detailed research and make a decision on one simple study. There is more evidence on the benefits of vitamin A," says Boca Raton, Florida dermatologist Dr. Marta Rendon.

However, Los Angeles dermatologist Dr. Ava Shamban is concerned with the potential consequences if the study results are proven correct when repeated with further testing involving sunscreen.

"If it is indeed true that UV or free radical exposure does convert the retinyl palmitate into a carcinogen, then there are multiple other anti-oxidants that are added to sunscreen that need to be checked to see if they turn into carcinogens as well when exposed to UV," says Shamban.

While the FDA isn't expected to announce the findings until next winter, the data is public information and can be viewed by anyone. But experts fear such preliminary information can cause people to prematurely make assumptions like those spread by recent email and blog blasts that often do not check sources nor cite accurate information.

"Be skeptical," advises Dr. Rendon.

In the wake of the controversy, consumer advocacy groups like the EWG are nevertheless showing outrage, as they say the 0.1% strength retinol tested in the study is 50 times lower than the highest five percent level of vitamin A that the industry currently considers safe for cosmetic use.

The group urges more stringent restrictions and consumer notification in the event that the safety of a substance like vitamin A is considered questionable, even if further testing needs to be done for final conclusions to be made.

"FDA's inaction has left consumers to wonder which of the hundreds of sunscreens on the market work best for themselves and their families," the EWG said in a statement.

On its website, the EWG also argues that the FDA has had concerns over the safety of vitamin A in personal care products for at least ten years, yet has lagged on regulation and informing consumers of the potential risks of vitamin A.

The FDA, however, says that they have been public with all information linked to the study in question.

"An external audit of the pathology data was conducted by NTP Pathology Working Group and the tables were posted on the NTP public website on July 15th, 2009," the FDA told StyleList.

So what is a confused consumer to do? Should we go on a clean-out binge?

"Do not throw away your sunscreen! Sunscreens are an important part of an overall sun protection plan which includes wearing a hat, sun protective clothing and seeking shade. Remember that every hour an American dies of melanoma, the most deadly form of skin cancer. Do not let this report stop you from using sunscreens," says Dr. Rendon.

That said, if you want to shop for sunscreens without Vitamin A, check out this list on our sister site, AOL Shopping.
Read All Comments
Filed under: Beauty, News, Skin & Body
Tags: ask-the-editor, Dr. Ava Shamban, Dr. Joshua Zeichner, Dr. Marta Rendon, Environmental Working Group, FDA, sunscreen, vitamin a
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READER COMMENTS

(4)Add A Comment

Catherine, 5-26-2010, 1:47PM

2 stars vote downvote upReport
Catherine

Why take the risk and slather on chemicals when there are safe, effective, nontoxic options. Check out the 2010 sunscreen guide with moisturizers, http://www.ewg.org/2010sunscreen/finding-the-best-sunscreens/?search=&brand_id=&ptype=moisturizer .These are great for everyday use for your face. I especially love Marie Veronique Organics. The medium tint is perfect for me. It's easy to wear (not greasy or pasty white) and provide full UVA/UVB protection.


Reply »

smilinggreenmom, 5-31-2010, 2:44PM

2 stars vote downvote upReport
smilinggreenmom

I agree! We use natural products whenever we absolutely can! It just makes sense. My worry though is that I just read somewhere that those with cracked skin/eczema should be worried about titanium etc seeping into the bloodstream from natural products or others that the EWG highlights. Our son has cracked skin due to severe eczema and I certainly do not want anything seeping in. I guess it is a matter of choosing the least offensive for us. Thankfully he is so much better now that he takes his Belly Boost children's chewable probiotics and I am thrilled - now if I could just get the sunscreen bit figured out.

Reply »

Sonya EWG, 6-01-2010, 3:01PM

2 stars vote downvote upReport
Sonya EWG

We find it ironic that you claim that EWG recommendation that consumers avoid retinyl palmitate (RP) isn't "based on evidence".

As EWG's report [www.ewg.org/2010sunscreen] explains, our concerns are based on raw data from the National Toxicology Program's (NTP's) 1 year cancer showing a significant effect between RP-laced creams and skin damage (tumor and lesion formation).

In a May 28, 2010 letter, [http://www.ewg.org/ewg-asks-fda-to-wind-up-study-of-vitamin-a-in-sunscreen] we ask the heads of FDA and NIEHS, co-sponsors of the study to expedite evaluating these data, and give consumers meaningful guidance on the safety of vitamin A in body care products.

Your concerns that animal studies cannot be used to predict risk for human skin are also misleading. It is unethical to test potential carcinogens on people when reliable laboratory methods exist. The tests performed by NTP on hairless mice, are considered the best way to determine if compounds react in sunlight to increase skin cancer risk. We think the existing data makes a compelling case for avoiding this ingredient.

Your post questions whether testing RP in creams is relevant to sunscreens. While UV filters may slow the disintegration of some unstable chemicals, such as RP, the fact that sunscreen wearers apply these products frequently and subject them to prolonged sun exposure, heightens our concerns about adverse effects.

Like you, we are awaiting clear guidance from FDA--the agency charged with evaluating the safety of sunscreen and other body care products. But the fact is that FDA's progress on sun protection is less than stellar. After 3 decades of effort it has still failed to set firm standards for labeling and sun protection. As a result sunscreens oversell their protective power and rely on poorly studied chemicals that might actually harm skin. Our sunscreen database is the only place consumers can look beyond the label and get information about the best way to protect their skin from the sun.

Reply »

Guest, 6-15-2010, 12:57AM

2 stars vote downvote upReport
Guest

@smilinggreenmom
Interestingly enough, the NTP was also testing a "natural" substance for photo-carcinogenesis in a manner similar to the vitamin A test. Creams based on aloe vera or various aloe extracts were slathered on the same hairless hairless mice exposed to simulated sunlight.

The aloe mice got cancer about as often as mice wearing aloe-free cream or no cream, but there were more tumors per aloe mouse. (Note that the researchers use the statistician's definition of "significant". It just means "unlikely to have happened by chance" and does not necessarily mean "important".)
http://ntp.niehs.nih.gov/index.cfm?objectid=84BA2E41-F1F6-975E-74710B3802656C9C#

Like the vitamin A test, the results are in, but a risk-assessment paper is still in the works.

Reply »

 
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