"Sometimes I use Botox," 46-year-old Cox, who was photographed by Jenny Gage and Tom Betterton, tells the magazine.
"Aging gracefully is one thing, but trying to slow it down is another."
Time certainly seems to have stood still for the "Cougar Town" actress, who, unlike most other middle-aged Hollywood A-listers, is taking measures not to become a needle junkie.
"Compared to most, I use it very sparingly," says Cox, who poses inside the pages wearing knee-high black boots, a black sweater draping down across one shoulder to reveal the strap of her naughty black teddy, and sexy bed head.
Though she keeps the Botox boosts to a minimum, Cox confesses that she did have a bad experience with the botulism injections in the past.
Ultimately, however, she's comfortable in it. "I don't have a problem with any of that stuff," Cox says of cosmetic procedures. "If it makes you feel better about yourself and it's done properly, then fine."
Psst, Courteney, can we have the name of your doctor?
For more of Cox's interview and additional photos, pick up the August issue of InStyle, out July 16, and visit InStyle.com to check out the star's best red-carpet moments, her evolving style, and even see how you would look with her locks.
In related "Friends" news, uh, have you seen David Schwimmer's hair lately?