Eva MendesFall/Winter Vs. magazine cover patient in mental institute

Eva Mendes drives us (and herself) crazy in new Vs. magazine photo shoot.

She's off her frocker!

Eva Mendes gets nutty in a campy fashion spread for the Fall/Winter issue of Vs. magazine, playing a bewigged patient in a mental institute.

Though the recent Allure cover girl strikes a typically sultry pose for the black-and-white cover, the accompanying "We're All Crazy for Eva" shoot with photographer Ellen von Unwerth takes a loopy turn.

The former Calvin Klein spokesmodel wears a red dress as she resists a nurse's attempts to restrain her in one photo, while another image sees her donning a blonde wig and a red suit as she calls for help.

Mendes -- rocking a long black wig, harem pants, and a semiconscious pose -- also bums a smoke from a nurse, tries to climb the hospital fence in a teased red do, and gets busted throwing her blonde wig in the pool.

All that's missing is the Lady Gaga-style straitjacket.

Naomi Campbell, Christina Ricci, and Rachel Weisz also appear on alternate covers of the issue, which is on sale now.

Eva Mendes red dress Vs Magazine

Restrain yourselves. A nurse tries to tame a mad Mendes in Vs photo shoot. Photo: Ellen von Unwerth / Vs. Magazine

Meanwhile, check out Lady Gaga's controversial meat bikini on the cover of Vogue Hommes Japan.