Nominated in a record 13 categories, the sirloin-ed singer changed into increasingly outlandish outfits throughout the ceremony.
Gaga stepped onto the white arrivals carpet wearing a full-length Alexander McQueen gown from the late designer's last collection. The crimson, gold, and olive dress unfurled over a frothy tulle underlay.
Her pale hair was worn long and softly waved, with patches of blue. Lest the Lady appear a bit too Queen Mum, she topped her look with a gold feathered Mohawk headdress.
She also wore McQueen's infamous Armadillo shoes, the 10-inch heels reminiscent of lobster claws. (The footwear is so hard to walk in, some models refused to wear them.)
When summoned to accept her award for the year's best pop video, Gaga had to be hauled to her feet, as she was wearing a hefty, custom-made, black leather gown by Giorgio Armani.
Once at the mic, she admitted that the dress was "too heavy to walk in... fashion roadkill, that's OK." Armani has designed several jaw-dropping ensembles for Gaga, including some of her Monster Ball tour costumes.
The sweeping bustled skirt was offset with tough spikes sprouting from her bustier and a black spiked Mohawk headpiece. A tassel like a vicious cat-o'-nine-tails dangled from her nape.
Gaga saved the most out-there outfit for last. She climbed onstage for the best video statuette wearing an outfit resembling a flayed cow by designer Franc Fernandez.
Beefy flaps and a fatty draped bodice made up the minidress. Her shoes resembled loins tied in butcher twine, and a steak perched like a beret on her head.
How to accessorize? No, not with a hot grill and fries -- with giant glittering bracelets and a choker, of course.
Though skimpy, the getup covered more than the meat bikini she slathered on for a recent cover of Vogue Hommes Japan magazine.
"I never thought I'd be asking Cher to hold my meat purse," Gaga quipped. She then announced the title of her next record: "Born Like This."
We just hope her seat was covered with plastic wrap.
Plus, check out what other celebs rocked at the 2010 MTV VMAs.