"I am delighted to confirm our second U.S. store will open in Chicago in the autumn of 2011," Mary Homer, Topshop's managing director, tells StyleLIst.
"A bustling, vibrant city of culture with a dynamic love of fashion, I feel confident that the local community and tourists alike will be drawn to Topshop and our trend-driven, ever-evolving ranges."
The whopping, 30,000-square-foot store will open in a corner location on the city's tony Michigan Avenue, next to Filene's Basement.
"Michigan Avenue is steeped in history and this impressive building provides the perfect backdrop for us to launch our most innovative retail concept yet," says Homer.
The chain's Topshop and Topman lines will both be represented in what is set to be the second U.S. location (New York City's SoHo store is the first).
Topshop's owner, Sir Philip Green, told WWD the merchandise "will not be materially different" from that of SoHo or London's Oxford Circus flagship.
The next cities targeted for the British brand's expansion are Las Vegas, San Francisco, and Los Angeles, with Miami and a second New York location in the plans.
The final full Kate Moss for Topshop collection will not be in the Chicago store, as it is launching in London on Nov. 4. Fingers crossed that her periodic capsule collections do make an appearance in the Windy City.
In related retail news, check out what Target has in store for its urban outposts.