Guests included honorees Sean Penn, New York mayor Michael Bloomberg, Glamour magazine editor Cindi Leive, models Crystal Renn and Paulina Porizkova, writer Nora Ephron, Bravo's Andy Cohen, Oprah Winfrey's BFF Gayle King, and Twitter founder Biz Stone.
"A game changer is someone who has the ability to challenge conventional wisdom and to look for opening where others don't see openings, and to be really willing to take risks," said Huffington, who was wearing a Ports 1961 metallic top and black pants, paired with Bulgari jewelry.
Bravo personality Bethenny Frankel walked the red carpet wearing a red Michael Kors dress and Brian Atwood shoes.
"The next season of my show will probably air in the spring, but it will not have the same name," said the star of "Bethenny Getting Married?" (A little bird inside the party said the next season might feature another pregnancy, and have the title "Bethenny Having a Baby?")
Frankel said of Huffington: "She's such a visionary, and it's so humbling to be included, because I did not think of myself on par with these people."
StyleList even caught up with former New York governor turned CNN talk show host Eliot Spitzer. "It's fun, I love it," he said of his new gig. "We're trying to zero in on the tough issues. You hate to reduce things to sound bites because the issues these days are complicated and simplification doesn't generate the sort of understanding we want."
(Personally, governor, we'd go with the sound bite every time.)
From the podium, Mayor Bloomberg shared some banter with Nora Ephron, who has just released a book called "I Remember Nothing" -- "which is also the title of a book by Charlie Sheen," he joked.
Finally, we couldn't resist asking Cohen about the recent professional breakup of Rachel Zoe and Brad Goreski, who announced that he would not be returning for the next season of "The Rachel Zoe Project." Does that mean we should expect an impending announcement that he might be getting his own show?
"There could always be an impending announcement," said Cohen with a twinkle in his eye. "But until there is, I keep my mouth shut."
In related news, check out StyleList's dishy interview with Goreski.