Isabelle Caro was featured naked in a shocking 2007 ad campaign to highlight the ailment, and brought Jessica Simpson to tears when she was interviewed in her television documentary series, "The Price of Beauty."
Although her death was only announced today, her acting coach said that she actually passed away on Nov. 17 while working in Tokyo.
Her billboard campaign, which was shot by photographer Oliviero Toscani and endorsed by the Italian Ministry of Health, ran in Milan to coincide with that city's Fashion Week. It was meant to raise awareness within the fashion industry about the eating disorder, but proved controversial with designers.
At the time, StyleList reported that Giorgio Armani challenged the connection between anorexia and the fashion industry, saying, "even people who take no notice of fashion get anorexic."
Designers Dolce and Gabbana said that anorexia is a psychological ailment that has "nothing to do with fashion."